… Here we focus on novel models developed in recent years; details for established models
are covered elsewhere (Shen and Abate-Shen 2010; Hensley and Kyprianou 2012; Ittmann et …

… to assess the biology, the grade of development of the tumor and … The hypothesis of the
mutational field may help not only to … -positive prostate cancer could benefit from novel inhibitors …

… working hypotheses can be generated, such as modulation of a particular biological pathway
that … CADD campaign, we will discuss our recent discovery of novel AR DBD inhibitors, (42) …

… of drug discovery, this review focuses on non-cancer drugs that … novel small molecules or
drug compounds through initiating with a hypothesis or generating new hypotheses about how …

… cancer. Finally, we describe a mathematical model of the relation between the structure and
biological … is also the hypothesis that the increased proliferation of breast cancer cells is …

… Castration-resistant prostate cancer (CRPC) is characterized by reactivation of androgen …
axis to treat prostate cancer that has become resistant to standard antiandrogen therapy. …

… drug resistance in several cancer cell lines both in vitro and in vivo, including advanced prostate
cancer, breast cancer… These results support the hypothesis that prevention of resistance …

… has provided support to his hypothesis, and now inflammation … trials were published utilizing
these biological treatments in GC. … Therefore, their future in the drug development process in …

… is to describe their discovery and biological functions in the … There is increasing evidence
supporting the hypothesis that … to screen patients with prostate cancer and for early diagnosis. …

… to explore other drug development strategies for PARP1. … To further verify the abovementioned
hypothesis, we sought to … To further support the above hypotheses, we evaluated the …